Formulation of innovative therapeutic strategies based on viral vectors, nanoparticles, chimeric aptamers and monoclonal antibodies. This group has expertise in the production of vectors derived from retroviruses, lentiviruses, adenoviruses and adeno-associated viruses, and can also generate cell banks that produce human monoclonal antibodies, known as research cell banks (RCB)
Immunotherapy Technology Center (NuTI) Home /Advanced health technologies Immunotherapy is a clinical mode of treating cancer that complements conventional therapies like surgery, radiation therapy, and chemotherapy. While surgery and radiotherapy are used for local treatment, chemotherapy and immunotherapy are applied systematically. Chemotherapy blocks non-specific mechanisms associated with cell division, while immunotherapy stimulates the immune system…
Biologicals Home /Advanced health technologies Medications derived from biotechnological processes have revolutionized therapeutic strategies for various diseases. Recombinant proteins like the monoclonal antibodies used to treat cancer, for example, are produced in cell lines. These, in turn, must be established in laboratory structures that are equipped to construct vectors for expression, cell transfection, selection of…
This center uses innovative biomaterial formulations and bioprinting technologies to develop 3D cell models. It focuses on creation of in vitro models as alternatives to animal testing and on progress in advanced therapies, with emphasis on the development of biodressings
Tissue Engineering Technology Center (NuTET) Home /Advanced health technologies The Tissue Engineering Technology Center (NuTET) develops innovative tissue engineering solutions with a focus on regeneration, replacement and repair of human tissues. Using technologies like 3D bioprinting and microphysiological systems, NuTET’s activities range from formulation of biomaterials to creating three-dimensional cell cultures, with applications in regenerative…
This center is dedicated to establishing gene therapy strategies using CRISPR/Cas9, base editing and prime editing to treat diseases that still do not have cures. The team has also been working to optimize encapsulation and delivery of these advanced therapy products (ATP) to develop safer and more effective treatments
Gene Editing Technology Center (NuTEG) Home /Advanced health technologies Gene therapy is an innovative treatment and one component of what are known as advanced therapy products (ATP). For more than a decade this area has been evolving worldwide, bringing promising advances in the treatment of human diseases. In late 2023, regulatory agencies in the US…
This center develops mass spectrometry proteomics methods to identify and quantify proteins and peptides, including spatial, structural, single-cell and computational proteomics. The work focuses on discovery and validation of molecular signatures with diagnostic, prognostic and therapeutic potential that are aligned with precision medicine and health innovation
Proteomics Technology Center (NuTeP) Home /Advanced health technologies The Proteomics Technology Center (NuTeP) works to develop mass proteomics approaches based on mass spectrometry using different acquisition methods (DDA, DIA, PRM, SRM) to explore various biological microenvironments. The robustness of proteomic analysis lies in its ability to reveal potential biomarkers and therapeutic targets; NuTeP specifically applies…
Drug discovery Home /Advanced health technologies The Drug discovery group works to leverage pharmaceutical innovation in Brazil, combining two of the country’s main competitive differentials: its rich biodiversity and cutting-edge research and science infrastructure. To do so, a platform was created that allows discovery initiatives to be carried out in a fluid and effective manner.…