Nuclear Magnetic Resonance Laboratory

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About the facility

This facility focuses on evaluating the structure and activity of proteins and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA, and carbohydrates), as well as identifying modifications in metabolic profiles and potential alterations in metabolic pathways in different biological matrices. Nuclear magnetic resonance is a technique also used to evaluate lignins, polymers and to elucidate the structure of small molecules.

How to submit research proposals

The Nuclear Magnetic Resonance lab operates on a continuous basis. Proposals can be submitted any time during the year, though the SAU Online portal. If you have any questions, e-mail the CNPEM User Office at edu@cnpem.br.

PROPOSAL SUBMISSION

PREPARE YOUR SAMPLE

Equipment

  • Agilent DD2 500 MHz spectrometer, with 5 mm triple resonance inverse probe (HCN) and 31P observation option;
  • 600 MHz Burker Avance NEO spectrometer, with 5 mm triple resonance cryogenic probe (HCN) and 19F observation option.

Main competencies and techniques

  • Protein structure determination using 3D pulse sequences
  • Protein interaction and dynamics using 2D heteronuclear or saturation transfer techniques
  • Identification and modification of metabolic profiles in biological matrices
  • Evaluation of lignins, polymers and copolymers
  • Diffusion techniques (DOSY) for evaluating interactions and compound formation
  • Structural evaluation of organic compounds

meet our team

Mauricio L. Sforça

Lead specialist (coordinator)

rmn@lnbio.cnpem.br

Silvana Aparecida Rocco

Researcher

Gustavo H. R. da Silva

Specialist

Irene L. Sousa

Specialist