Target Discovery and Validation
Identifying therapeutic targets with the objective of developing new treatments for human diseases
The work of the Drug Discovery Division spans from generating the biological hypothesis for pharmaceutical innovation to obtaining the candidate drug. Its mission is to drive radical innovation in pharmaceuticals in Brazil, through sustainable use of biodiversity in synergy with cutting-edge science and advanced technology. It uses a drug discovery platform that incorporates structural biology; bioassays; natural product biotechnology; natural product, medicinal and synthetic chemistry; as well as advanced computing. This integration allows the generation of customized experimental and computational methods for drug discovery and development of new bioactive compounds.
Within this context, the group leads drug discovery projects that accelerate TRLs 2-4, fostering interactions between ICTs, local communities and industry (from startups to large companies) in networks linked to the platform. This also guides the innovation ecosystem towards solving national challenges, such as consolidating the knowledge economy and strengthening pharmaceutical innovation as pillars of ecological transition and One Health in Brazil. Its values include social, regional and technological inclusion, aligning local vocations with national and global health demands.
Identifying therapeutic targets with the objective of developing new treatments for human diseases
This group promotes the advancement of knowledge related to the chemistry of natural products through the development and application of innovative pipelines with a focus on discovering new drugs and preserving Brazil’s biodiversity
Large-scale search for bioactive molecules through biochemical and cellular assays, integrative structural biology and biotechnology applied to drug discovery and development
Develops molecules with properties suitable for proving efficacy in animal models, an essential step in pharmaceutical development
The division connects Brazil via molecules, advanced methods and innovation initiatives, with global impact and local co-development
Expanding the understanding of diseases, identifying molecular targets for personalized therapies, and translating discoveries into health benefits
Implementing methods for scientific results on the cutting-edge of knowledge, playing a vital role in developing and new experimental approaches and putting them into action
Expanding our understanding of the mechanisms of viral and bacterial illnesses and those that affect neglected populations, such as Chagas disease
Enables radical innovation in pharmaceuticals in Brazil through the sustainable use of biodiversity in connection with cutting-edge science and high technology