Proteomics Technology Center (NuTeP)

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The Proteomics Technology Center (NuTeP) works to develop mass proteomics approaches based on mass spectrometry using different acquisition methods (DDA, DIA, PRM, SRM) to explore various biological microenvironments. The robustness of proteomic analysis lies in its ability to reveal potential biomarkers and therapeutic targets; NuTeP specifically applies these resources to head and neck cancer, the seventh most common type of cancer worldwide and the fifth in Brazil.

Despite advances in diagnosis, prognosis and therapeutic modalities, clinical challenges persist in this disease, including late diagnosis, lymph node metastases, local recurrences, poor response to treatment and reduced survival rates. For this reason, efforts have focused on translating knowledge from basic science into clinical practice, by transfer of proteomics methods as well as development of intelligent biosensors, thus helping to advance precision medicine.

Main findings and scientific publications

Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer

Busso-Lopes AF, Neves LX, Câmara GA, Granato DC, Pretti MAM, Heberle H, Patroni FMS, Sá J, Yokoo S, Rivera C, Domingues RR, Normando AGC, De Rossi T, Mello BP, Galdino NAL, Pauletti BA, Lacerda PA, Rodrigues AAN, Casarim ALM, de Lima-Souza RA, Damas II, Mariano FV, Gollob KJ, Medina TS, Cervigne NK, Prado-Ribeiro AC, Brandão TB, Villa LL, Uno M, Boroni M, Kowalski LP, González-Arriagada WA, Paes Leme AF

Mapping the Interactome of OSCC Prognostic-Associated Proteins NDRG1 and PGK1 Through Proximity Labeling Using TurboID

Câmara GA, Yokoo S, Granato DC, Simabuco FM, Ribeiro-Filho HV, Melo RM, Pauletti BA, Nascimento Filho EG, Domingues RR, Paes Leme AF

Mapping Conformational Changes in the Saliva Proteome Potentially Associated with Oral Cancer Aggressiveness

Granato DC, Carnielli CM, Trino LD, Busso-Lopes AF, Câmara GA, Normando AGC, Filho HVR, Domingues RR, Yokoo S, Pauletti BA, Patroni FM, Santos-Silva AR, Lopes MA, Brandão TB, Prado-Ribeiro AC, Lopes-de Oliveira PS, Telles GP, Paes Leme AF

meet our team

Adriana Paes Leme

Group Leader

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Ariane Fidelis Busso Lopes

Adjunct Researcher

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Carolina Moretto Carnielli

Adjunct Researcher

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Daniela Campos Granato

Adjunct Researcher

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Larissa Bueno Tofani

Specialist

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