Protein Design
This group focuses on engineering proteins with specific properties, for applications in biotechnology, therapies, and to study molecular mechanisms
Nuclear Structure
Nuclear Structure Home /Biologia integrativa The Nuclear Structure Group at LNBio/CNPEM emerged with a mission to reveal how the physical organization of the genome influences its function and, in turn, cell health. Using cutting-edge technologies in microscopy, structural biology and modeling, the group investigates how DNA folds, organizes and communicates within the nucleus. The focus…
Nuclear Structure
Works to reveal the three-dimensional structure of the genome and its relationship to gene expression and essential cellular processes
Protein Design
Protein Design Home /Biologia integrativa The ability to expand the known universe of protein amino acid sequences, through de novo design or protein engineering, permits a wide array of possibilities: from optimizing the properties of existing proteins to creating proteins with new functions and structures, with broad biotechnological and therapeutic applicability. Recent advances in the…
Computational biology
Computational biology Home /Biologia integrativa The areas of biotechnology have benefited significantly in recent decades from advances in science and technology which have led to the production of large quantities of data on biological systems. Today, a biological process can be approached considering gene architecture, protein structure and diversity, as well as the diversity of…
Non-Membrane Organelles
Investigates the formation, function and regulation of biomolecular condensates formed by phase separation, with direct impacts in the understanding of genomic regulation and metabolism
Non-Membrane Organelles
Non-Membrane Organelles Home /Biologia integrativa Non-membrane organelles are cellular structures that do not have a lipoprotein membrane surrounding them. Most of these organelles are made up of biomolecular condensates composed of proteins and nucleic acids, and play fundamental roles in regulating complex biological processes and maintaining cellular functions. With advanced techniques in molecular, cellular and…
Molecular and Cellular Sociology
Investigates molecular and cellular interactions in living tissue, with a focus on metabolic adaptation, tumor immunosuppression and development of personalized therapies
Molecular and Cellular Sociology
Molecular and Cellular Sociology Home /Biologia integrativa LNBio’s Molecular and Cellular Sociology Group is dedicated to the study of functional interactions between molecules and cells within the native tissue environment, with a focus on understanding the mechanisms that sustain the progression of diseases such as cancer. This group investigates how proteins, enzymes and molecular complexes…