Computational biology
Develops precise computational models to understand biomacromolecular systems, accelerating the production of experimental findings
Develops precise computational models to understand biomacromolecular systems, accelerating the production of experimental findings
Computational biology Home /Biologia integrativa The areas of biotechnology have benefited significantly in recent decades from advances in science and technology which have led to the production of large quantities of data on biological systems. Today, a biological process can be approached considering gene architecture, protein structure and diversity, as well as the diversity of…
Working to improve heart failure through therapies that regenerate cardiomyocytes, using advanced analytical and imaging techniques
Cardiology Home /Biologia integrativa During the first days after birth, the heart exhibits significant regenerative capacity, but the adult heart has limited capacity to regenerate after a heart attack. Because of this difference, researchers at LNBio are focusing on understanding the molecular mechanisms behind the loss of this regenerative capacity in the adult heart in…
This group models neurodegenerative diseases in animals and human induced pluripotent stem cells (hiPSC), correlating data and exploring functional models
Neurodevelopment and multi-scale connectivity Home /Biologia integrativa The process of neurodevelopment, from the formation of the nervous system to configuration of the neural circuitry, is extremely complex. A multi-scale approach is utilized to understand cerebral plasticity, which is essential for adaptation to environmental demands. This approach includes techniques like multinomics, 3D imaging, and scientific computation…
Dedicated to the study of molecular mechanisms associated with intellectual impairment, investigating mutations and the impact on the nervous system to improve diagnostics and treatments
Biomolecular condensates Home /Biologia integrativa Biomolecular condensates are composed of proteins and other biomolecules that aggregate in liquid-liquid or liquid-solid structures inside the cells, and perform essential roles in regulating complex biological processes and maintaining cell functions. LNBio stands out in studying the molecular mechanisms of human proteins with critical roles in health and disease.…
Investigating the molecular foundations of cancer, studying its development in natural microenvironments
Cancer biology Home /Biologia integrativa Improving the treatment options for diseases like cancer requires continuous evolution of the disease models used in the laboratory. Three-dimensional culture of tumor cells in the form of organoids has proven an important method for establishing personalized therapies. This approach makes it possible to replicate tumors in lab conditions and…