High-throughput screening (HTS) is a scientific experimentation technique that makes it possible to conduct automated biochemical or cellular assays on thousands of chemical samples, from synthetic or natural sources, using the smallest possible quantities of reagents
Advanced methodologies have revolutionized our understanding of biological processes in health and in illnesses, offering new opportunities for early diagnosis, to develop personalized therapies, and to discover prognostic biomarkers
The group’s objective is to test technology and expertise to evaluate the structure and activity of proteins and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA, and carbohydrates), making it possible to identify modifications in metabolic profiles and potential alterations in metabolic pathways
Group specializing in the synthesis of peptides and DNA and RNA oligonucleotides, as well as the purification, characterization and crystallization of proteins and their complexes. Consists of four open facilities with state-of-the-art technology, modern equipment and highly qualified staff to support a wide range of scientific projects. Combines expertise in the chemical synthesis of biomolecules, as well as in the biophysical, functional and structural characterization of proteins and the study of their interactions. This integration between knowledge and technology allows the scientific community to carry out innovative research, driving discoveries and studies that benefit various areas of knowledge
ROBOLAB is a laboratory specializing in the crystallization of macromolecules and their complexes, with a focus on automation, high-throughput, and accessibility for the scientific community. It offers complete support for crystallization experiments with state-of-the-art technologies, substantially boosting the chances of obtaining quality crystals for structural studies via X-ray diffraction
This facility makes it possible to conduct biophysical studies of macromolecules, nanoparticles, and polymers in solution. Providing information about structure, coiling, molecular binding, dissociation constants, stability, size, shape, and oligomeric state
Nuclear magnetic resonance is an alternative technique that is widely used to resolve the atomic structure of proteins, particularly those with low molecular weights which do not form crystals
Proteomics based on state-of-the-art mass spectrometry for CNPEM’s internal and external users. The MAS lab comprises the sample preparation lab, the instrumentation lab, and the data analysis lab
Projeto do CNPEM com universidade holandesa disponibiliza bolsa de PD em Engenharia de Tecidos O Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), em parceria com o Radboud University Medical Center (Radboudumc), nos Países Baixos, dispõe de uma vaga de pós-doutorado, com apoio da Fundação de Amparo à Pesquisa do Estado de São Paulo…
