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Innovation
Our mission is to promote innovation in Brazil through RDI partnerships, support companies in the development of projects, scaling-up, and transfer of technology and know-how, and meet the needs of high-complexity companies.
CNPEM’s Innovation Support Assistance department (AIN) is the entryway for companies to take advantage of the competencies offered by the Brazilian Biosciences National Laboratory (LNBio). This department works to prospect, and negotiate projects in collaboration with companies and services involving high technological complexity, formalize partnerships, and protect intellectual property.
At LNBio, cutting-edge services are offered in the area of molecular and structural biology, including mass spectrometry-based proteomics, protein characterization by spectroscopy and calorimetry, as well as molecular structures studies and biomolecular interactions by nuclear magnetic resonance. These approaches allow everything from protein identification and quantification, post-translational modifications and metabolic profiles, to in-depth understanding of protein structures, biological activity and cell signaling, contributing to advances in basic and applied research, markers and therapeutic targets discovery, drug development and biotechnological products quality improvement.
Mass Spectrometry (MS)-Based Proteomics (MAS)
The laboratory has mass spectrometers coupled to liquid chromatography (LC-MS/MS) and carries out the following analyzes: primary sequence analysis on simple or complex samples; molecular mass analysis; relative quantification and identification of post-translational modification (phosphorylation, acetylation, glycosylation and disulfide bond, among others); large-scale quantitative proteomic analysis (relative quantification and identification of proteins in complex samples); single cell proteomics.
Spectroscopy and Calorimetry (LSC)
The biological activity of proteins is intrinsically associated with the different levels of structures presented by these molecules. Consequently, protein’s higher-order structure (HOS) is a critical quality parameter, since changes in this parameter may impact the reproducibility, quality, efficacy, safety, stability and immunogenicity of an application or formulation. In this context, our laboratory offers different types of complementary and orthogonal analyses, intended for the analysis and determination of protein’s higher-order structure. Furthermore, we carry out comparative analyzes between different batches of innovative samples and between innovative samples and benchmark products.
Nuclear Magnetic Resonance (NMR)
LNBio’s NMR Laboratory is a multi-user facility focused on assess different diseases correlating proteins structure and activity and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA and carbohydrates); uncover changes in metabolic profiles and possible alterations in metabolic pathways and; determine the structural configurations of small molecules originating from natural or synthetic products. To do so, we use homonuclear, heteronuclear and multidimensional NMR techniques.
Technology showcase
Companies of all sizes in various sectors can boost their competitiveness and expand their technological profile by licensing the intellectual property developed at the CNPEM. The Innovation Support Assistance department negotiates and takes care of the entire licensing process