Medicinal Chemistry

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Develops molecules with properties suitable for pharmaceutical candidates with efficacy in animal models, an essential step in pharmaceutical development. Medicinal chemistry approaches are adopted for rational planning of new pharmaceutically active chemical substances. This work is guided by the analysis of bioassay results and the prediction of drug properties, and production of molecules is mediated by in-house organic synthesis methodologies.

Main findings and scientific publications

Competing interests during the key N-glycosylation of 6-chloro-7-deaza-7-iodopurine for the synthesis of 7-deaza-2′-methyladenosine using Vorbrüggen conditions

Fabrício Fredo Naciuk, Andrey Fabricio Ziem Nascimento, Rebeca Paiva Froes Rocha, Joane Kathelen Rustiguel, Lais Durço Coimbra, Rafael Elias Marques, Marjorie Bruder

Natural allosteric modulators and their biological targets: molecular signatures and mechanisms

Marjorie Bruder, Gina Polo, Daniela B. B. Trivella

Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor

Gustavo Fernando Mercaldi, Eduardo Henrique Salviano Bezerra, Fernanda Aparecida Heleno Batista, Celisa Caldana Costa Tonoli, Adriana Santos Soprano, Jacqueline Farinha Shimizu, Alice Nagai, Jaqueline Cristina da Silva, Helder Veras Ribeiro Filho, Jéssica do Nascimento Faria, Marcos Guilherme da Cunha, Ana Carolina Mattos Zeri, Andrey Fabricio Ziem Nascimento, José Luiz Proenca-Modena, Marcio Chaim Bajgelman, Silvana Aparecida Rocco, Paulo Sérgio Lopes-de-Oliveira, Artur Torres Cordeiro, Marjorie Bruder, Rafael Elias Marques, Mauricio Luis Sforça, Kleber Gomes Franchini, Celso Eduardo Benedetti, Ana Carolina Migliorini Figueira, Daniela Barretto Barbosa Trivella

meet our team

Marjorie C. P. Bruder

Lead Researcher

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Fabricio Fredo Naciuk

Specialist

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Anwar Shamin

Specialist

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Kelita Angelo de Paula

Analyst

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All groups in drug discovery