Advanced Omics Laboratory Home /Scientific divisions/Page 2 The Advanced Omics Laboratory (LOA) is a multidisciplinary space dedicated to sample processing for different omics applications, integrating flow cytometry technologies, high-precision cell sorting and single-cell analysis. Its infrastructure permits phenotypic and morphological characterization of cells, separation of specific subpopulations with high purity, and refined preparation of samples…
Nuclear Structure Home /Scientific divisions/Page 2 The Nuclear Structure Group at LNBio/CNPEM emerged with a mission to reveal how the physical organization of the genome influences its function and, in turn, cell health. Using cutting-edge technologies in microscopy, structural biology and modeling, the group investigates how DNA folds, organizes and communicates within the nucleus. The…
Protein Design Home /Scientific divisions/Page 2 The ability to expand the known universe of protein amino acid sequences, through de novo design or protein engineering, permits a wide array of possibilities: from optimizing the properties of existing proteins to creating proteins with new functions and structures, with broad biotechnological and therapeutic applicability. Recent advances in…
Drug Discovery Home /Scientific divisions/Page 2 Drug Discovery The work of the Drug Discovery Division spans from generating the biological hypothesis for pharmaceutical innovation to obtaining the candidate drug. Its mission is to drive radical innovation in pharmaceuticals in Brazil, through sustainable use of biodiversity in synergy with cutting-edge science and advanced technology. It uses…
In order to guarantee the high degree of purity and homogeneity required for biophysical and functional analyses, LNBio has a Protein Purification Laboratory (LPP), equipped with several semi-automated chromatographs that enable the main liquid chromatography techniques to be carried out
The Biomolecule Synthesis Laboratory emerged to provide institutional independence in obtaining certain types of biomolecules. Being able to generate raw materials on site provides speed and flexibility in the production of biomolecules for different types of research and applications
High-throughput screening (HTS) is a scientific experimentation technique that makes it possible to conduct automated biochemical or cellular assays on thousands of chemical samples, from synthetic or natural sources, using the smallest possible quantities of reagents
Advanced methodologies have revolutionized our understanding of biological processes in health and in illnesses, offering new opportunities for early diagnosis, to develop personalized therapies, and to discover prognostic biomarkers
The group’s objective is to test technology and expertise to evaluate the structure and activity of proteins and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA, and carbohydrates), making it possible to identify modifications in metabolic profiles and potential alterations in metabolic pathways
Group specializing in the synthesis of peptides and DNA and RNA oligonucleotides, as well as the purification, characterization and crystallization of proteins and their complexes. Consists of four open facilities with state-of-the-art technology, modern equipment and highly qualified staff to support a wide range of scientific projects. Combines expertise in the chemical synthesis of biomolecules, as well as in the biophysical, functional and structural characterization of proteins and the study of their interactions. This integration between knowledge and technology allows the scientific community to carry out innovative research, driving discoveries and studies that benefit various areas of knowledge