Estrutura nuclear Home /Scientific divisions O Grupo de Estrutura Nuclear do LNBio/CNPEM nasce com a missão de desvendar como a organização física do genoma influencia seu funcionamento — e, por consequência, a saúde celular. Utilizando tecnologias de ponta em microscopia, biologia estrutural e modelagem, o grupo busca entender como o DNA se dobra, se organiza…
Design de proteínas Home /Scientific divisions A possibilidade de expandir o universo conhecido de sequências de aminoácidos de proteínas, por meio do design de novo ou da engenharia de proteínas, viabiliza desde a otimização de propriedades de proteínas já existentes até a criação de proteínas com novas funções e estruturas, com ampla aplicabilidade biotecnológica e…
Design de proteínas Home /Scientific divisions A possibilidade de expandir o universo conhecido de sequências de aminoácidos de proteínas, por meio do design de novo ou da engenharia de proteínas, viabiliza desde a otimização de propriedades de proteínas já existentes até a criação de proteínas com novas funções e estruturas, com ampla aplicabilidade biotecnológica e…
Sociologia molecular e celular Home /Scientific divisions Improving the treatment options for diseases like cancer requires continuous evolution of the disease models used in the laboratory. Three-dimensional culture of tumor cells in the form of organoids has proven an important method for establishing personalized therapies. This approach makes it possible to replicate tumors in lab…
In order to guarantee the high degree of purity and homogeneity required for biophysical and functional analyses, LNBio has a Protein Purification Laboratory (LPP), equipped with several semi-automated chromatographs that enable the main liquid chromatography techniques to be carried out
The Biomolecule Synthesis Laboratory emerged to provide institutional independence in obtaining certain types of biomolecules. Being able to generate raw materials on site provides speed and flexibility in the production of biomolecules for different types of research and applications
High-throughput screening (HTS) is a scientific experimentation technique that makes it possible to conduct automated biochemical or cellular assays on thousands of chemical samples, from synthetic or natural sources, using the smallest possible quantities of reagents
Advanced methodologies have revolutionized our understanding of biological processes in health and in illnesses, offering new opportunities for early diagnosis, to develop personalized therapies, and to discover prognostic biomarkers
The group’s objective is to test technology and expertise to evaluate the structure and activity of proteins and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA, and carbohydrates), making it possible to identify modifications in metabolic profiles and potential alterations in metabolic pathways
The group specializes in the characterization of biomolecules, from the synthesis of oligonucleotides and peptides to the crystallization of proteins. Its expertise lies in the biophysical and structural characterization of proteins, macromolecules, nanoparticles and polymers in solution