Nuclear Magnetic Resonance Laboratory Home /Open facilities About the facility This laboratory focuses on evaluating the structure and activity of proteins and their interactions with small molecules (pharmaceuticals and drugs) or macromolecules (DNA, RNA, and carbohydrates), making it possible to identify modifications in metabolic profiles and potential alterations in metabolic pathways. Nuclear magnetic resonance is…
LNBio’s Bioassay Laboratory (LBE) specializes in carrying out bioassays using the High Throughput Screening (HTS) and High Content Screening (HCS) methods, contributing to significant advances in the research and development of new molecules with biotechnological and pharmaceutical applications
Biological imaging laboratory Home /Open facilities Biological imaging laboratory Funding: FINEP (Multi-user National Centers 02/2016), agreement 01.17.0024-00 The Biological Imaging Laboratory offers external users access to the Leica STED inverted super-resolution confocal microscope, which surpasses the diffraction limit of light, enabling the investigation of subcellular details in fixed biological samples. The equipment combines laser confocal…
The ROBOLAB is a high-throughput laboratory equipped for crystallization of macromolecules and their complexes. Its mission is to provide state-of-the-art technologies and equipment for crystallizing macromolecules, increasing the chances of success in obtaining crystals
This facility makes it possible to conduct biophysical studies of macromolecules, nanoparticles, and polymers in solution. Providing information about structure, coiling, molecular binding, dissociation constants, stability, size, shape, and oligomeric state
Proteomics based on state-of-the-art mass spectrometry for CNPEM’s internal and external users. The MAS lab comprises the sample preparation lab, the instrumentation lab, and the data analysis lab
Bioassays laboratory Home /Open facilities About the facility With a solid and well-established trajectory of over 15 years, the Bioassay Laboratory (LBE) at LNBio specializes in conducting bioassays using High Throughput Screening (HTS) and High Content Screening (HCS) methods. This automated approach, based on various miniaturized biochemical and cellular assays, enables the rapid and precise…
Protein purification Home /Open facilities LNBio has a complete structure for the production of recombinant proteins in heterologous systems, such as bacteria and insect cells. Currently, it offers academic users all the experience, structure, supplies and equipment for the complete production process using bacteria, from E. coli transformation to recombinant protein expression, purification and quality…
Biomolecule synthesis laboratory Home /Open facilities About the facility In 2021, LNBio inaugurated the Biomolecule Synthesis Laboratory (LSB) in order to serve CNPEM’s entire scientific community. By providing high-quality biomolecules for a wide array of lines of research, the LSB is a strategic laboratory that centralizes the production and distribution of materials that are essential…
Automatic Protein Crystallization Laboratory Home /Open facilities About the facility The ROBOLAB carries out all stages of the protein crystallization process, from preparing the crystallization matrices to distribution into microplates and periodic recording of the experiments. It also provides users a completely automated platform to screen crystallization conditions and view their experiments, which can be…