Bacteria

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The study of antibiotic-resistant gram-negative bacteria is critical, due to the global threat that bacterial resistance represents. There is an urgent need to develop new antimicrobials for several reasons, including the decline in new antimicrobial agents approved for clinical use and rising numbers of infections caused by drug-resistant bacteria. Within this context, LNBio is directing its efforts toward developing new antimicrobial compounds to combat these bacteria. To do so, it utilizes its capacity for large-scale testing of molecular libraries, along with X-ray crystallography and microscopy imaging, to study new targets present in pathogens that are significant for public health.

Main findings and scientific publications

Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium

Mercaldi, G. F., Andrade, M. O., Zanella, J. L., Cordeiro, A. T., & Benedetti, C. E. (2021)

Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box

Mercaldi, G. F., Eufrásio, A. G., Ranzani, A. T., do Nascimento Faria, J., Mota, S. G. R., Fagundes, M., Bruder, M., & Cordeiro, A. T. (2021)

Discovery of new uncompetitive inhibitors of glucose-6-phosphate dehydrogenase

Mercaldi, G. F., Ranzani, A. T., & Cordeiro, A. T. (2014)

meet
our team

Gustavo Fernando Mercaldi

Lead researcher

bacteria group
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