Biomolecular condensates

Biomolecular condensates are composed of proteins and other biomolecules that aggregate in liquid-liquid or liquid-solid structures inside the cells, and perform essential roles in regulating complex biological processes and maintaining cell functions.

LNBio stands out in studying the molecular mechanisms of human proteins with critical roles in health and disease. By combining advanced techniques in molecular, structure, and functional biology, mutations that affect the proper function of these proteins in patients with neurodevelopmental disorders can be analyzed. The goal is to identify small molecules that are able to modulate the functions of these proteins and understand how they affect the formation of biomolecular condensates.