Cardiology

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During the first days after birth, the heart exhibits significant regenerative capacity, but the adult heart has limited capacity to regenerate after a heart attack. Because of this difference, researchers at LNBio are focusing on understanding the molecular mechanisms behind the loss of this regenerative capacity in the adult heart in order to identify and develop new therapies.

Studies conducted by the group revealed for the first time that inhibiting the PDK4 enzyme promotes proliferation of cardiomyocytes, significantly improves cardiovascular function, and reduces pathological remodeling after a heart attack. Their findings suggest a promising role for inhibiting PDK4 as a cardioprotective and regenerative strategy to treat cardiac diseases.

Main findings and scientific publications

Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression. Nature Metabolism

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA

MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG

FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes

Cardoso AC, Pereira AHM, Ambrosio ALB, Consonni SR, Rocha de Oliveira R, Bajgelman MC, Dias SMG, Franchini KG

meet
our team

Alisson Cardoso

Lead researcher

cardiology group
See Lattes CV

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