Target Discovery and Validation

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The Target Discovery and Validation research group focuses on identifying and validating therapeutic targets in order to develop new treatments for human diseases. The process begins with research to understand the molecular mechanisms of diseases such as neurodegenerative, cardiovascular, and metabolic disorders as well as cancer, selecting and validating relevant molecular targets to develop new therapies. This involves uses genetic and pharmacological target validation approaches, as well as the initial development of in vitro and in vivo models to interrogate them.

Main findings and scientific publications

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Nature Metabolism, v. 2, p. 167-178, 2020

MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

EBIOMEDICINE, v. 51, p. 102571, 2020

FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes

STRUCTURE, v. 24, p. 1301-1310, 2016

meet our team

Alisson Campos Cardoso

Lead Researcher

See Lattes CV

Ana Helena Macedo Pereira

Specialist

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Andrea Coelho de Barros

Specialist

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Patrícia Nolasco Santos

Adjunct Researcher

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Taysa Bervian Bassani

Specialist

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All groups in drug discovery