Informações
Data: 20/05/2013 – 08:30:00
Fim: 20/05/2013 – 17:00:00
Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267
Detalhes
mTOR is a conserved kinase that integrates several stimuli, such as growth factors, stress, energy levels and nutrients, especially branched chain aminoacids, to regulate cellular metabolism and growth. The most studied substrates of mTOR kinase are S6K and 4E-BP, an inhibitor of the translation initiation factor eIF4E. mTOR regulates translation initiation by the phosphorylation of these two substrates.The dysregulation of mTOR kinase is related to the development of several types of cancer, type 2 diabetes and Alzheimer’s disease, and its inhibition can prevent aging and increase life span in animal models. However, the inhibition of its activity in the cardiac tissue may be beneficial or detrimental, depending on the context. This seminar will focus on the recent advances obtained by our group and collaborators on two research lines: the regulation of translation by the mTOR kinase and 4E-BP in the heart tissue and cells, and the structural bases of the leucine mediated signaling in the mTOR pathway.
Speaker: Dra. Juliana Smetana-LNBio
20th May at 8:30am
Sala 69 – LNBio
Campus – Centro Nacional de Pesquisa em Energia e Materiais – CNPEM
Rua Giuseppe M. Scolfaro, 10.000 – Guará
Telefone: (19) 3512-1010
