Informações
Data: 22/05/2014 – 09:00:00
Fim: 22/05/2014 – 17:00:00
Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267
Detalhes
Abstract: The Hedgehog (Hh) signaling pathway plays critical roles in embryonic patterning, tissue homeostasis, and tumorigenesis. In this seminar I will describe our laboratory’s use of genetic and chemical screens to identify new regulators of the Hh pathway. Using a genome-scale, flow cytometry-based survey of human cDNAs, we have discovered a novel signaling protein that activates Gli transcription factors in a non-canonical manner and may promote the onset and/or progression of medulloblastoma, the most common pediatric brain cancer. We have also used large-scale chemical screens to discover two new classes of synthetic Hh pathway inhibitors. One compound class represents the first specific antagonists of cytoplasmic dynein, and the other inhibits Gli function in an isoform-selective manner. Taken together, our findings shed new light on the etiology of Gli-dependent cancers and suggest future strategies for their therapeutic control.
Speaker: James K. Chen, Ph.D. – Departments of Chemical and Systems Biology, Developmental Biology, and Chemistry, Stanford University.
22nd May 2014 at 9:00am
Room 69 – LNBio
Campus – Centro Nacional de Pesquisa em Energia e Materiais – CNPEM
Rua Giuseppe M. Scolfaro, 10.000 – Guará
Telefone: (19) 3512-1010
