Arquivo de Categoria: Eventos

Seminar: “Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival”

Informações Data: 25/03/2013 – 08:30:00 Fim: 25/03/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Glioblastomas (GBMs) are resistant to current therapy protocols and identification of molecules that target these tumors is crucial. Interaction of secreted Hsp70-Hsp90 organizing protein (HOP) with cellular…

Seminar: “Modulating the reactivity of the proteasome with natural product based inhibitors”

Informações Data: 01/04/2013 – 08:30:00 Fim: 01/04/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Proteasome inhibition is clinically validated as chemotherapy and is highly restricted to a select group of electrophiles. In this talk will be presented the molecular basis of…

Seminar: “The role of members of Nek family kinases in the regulation of mitotic progression and in the DNA damage response”

Informações Data: 08/04/2013 – 08:30:00 Fim: 08/04/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes The founding member of the kinases Nek family (NIMA related kinase) is the protein NIMA (Never in mitosis A) of Aspergillus nidulans. The loss of its function…

Seminar: “Fragment-based methods for drug discovery and chemical biology”

Informações Data: 15/04/2013 – 08:30:00 Fim: 15/04/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes We have developed several approaches based on different biophysical methods to identify low affinity fragments binding to macromolecules. These fragments act as starting points for subsequent elaboration…

Seminar: "Origins of the vertebrate heart: a paleontological study of the cardiovascular system from the Araripe basin".

Informações Data: 22/04/2013 – 08:30:00 Fim: 22/04/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes An important aaproach to test the various hypotheses about the origin of the vertebrate chambered heart would be the analysis of the fossil record, especially from animals…

Seminar: "In silico prediction of macromolecular complexes"

Informações Data: 06/05/2013 – 08:30:00 Fim: 06/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Proteins are prodigal molecules in binding to other chemical entities, either organic or inorganic; these interactions are mostly related to the diversity of organic radicals neatly distributed in the space by thermodynamicallyfolding of the polypeptide chain. This spatial organization allows either the…

Symposium: Advances and limitations in drug discovery for trypanosomiases and leishmaniasis

Informações Data: 06/05/2013 – 14:00:00 Fim: 06/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Tropical neglected diseases are a group of diseases that affect underprivileged populations and are characterized by the lack of pharmaceutical R&D investments. In this group, leishmaniasis and…

Seminar: “Proteomics of Tumor Microenvironment: Potential Roles in Carcinogenesis, Tumorigenesis and Metastasis”.

Informações Data: 14/05/2013 – 08:30:00 Fim: 14/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Speaker: Dr. Jay W. Fox – University of Virginia 14th May at 8:30am LNBio – Room 69 Campus – Centro Nacional de Pesquisa em Energia e Materiais…

Seminar: "The mTOR kinase pathway in cancer development and heart failure."

Informações Data: 20/05/2013 – 08:30:00 Fim: 20/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes mTOR is a conserved kinase that integrates several stimuli, such as growth factors, stress, energy levels and nutrients, especially branched chain aminoacids, to regulate cellular metabolism and growth. The most studied substrates of mTOR kinase are S6K and 4E-BP, an inhibitor of the translation initiation factor eIF4E. mTOR regulates translation initiation by the phosphorylation of these two substrates.The dysregulation of mTOR kinase is related…

Seminar: "Structural Studies, Biosynthesis and Biological Activities of Secondary Metabolites from Marine Organisms".

Informações Data: 27/05/2013 – 08:30:00 Fim: 27/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes Marine invertebrates and microorganisms have been the subject of much interest during the past decades due to their production and/or accumulation of structurally unique metabolites with potent…