Seminar: "The mTOR kinase pathway in cancer development and heart failure."
Informações Data: 20/05/2013 – 08:30:00 Fim: 20/05/2013 – 17:00:00 Onde: CNPEM – Rua Giuseppe Máximo Scolfaro, 10.000 – Campinas, SÃO PAULO 13280000 Brazil – Telefone: 19 35121267 Detalhes mTOR is a conserved kinase that integrates several stimuli, such as growth factors, stress, energy levels and nutrients, especially branched chain aminoacids, to regulate cellular metabolism and growth. The most studied substrates of mTOR kinase are S6K and 4E-BP, an inhibitor of the translation initiation factor eIF4E. mTOR regulates translation initiation by the phosphorylation of these two substrates.The dysregulation of mTOR kinase is related…