Seminar: Structural and functional insights into the multilayered mechanisms involved in intracellular transport mediated by class V myosins
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilAbstract: Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes, and regulatory proteins. In this seminar, we will present our recent results in this theme including the elucidation of the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc) and […]
Seminar: Ubiquitin and Ubiquitin-like proteins in plant stress signalling
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilSpeaker: Dr. Ari Sadanandom - Durham University, England 2nd April 2014 at 10:30am Room 69 - LNBio Campus – Centro Nacional de Pesquisa em Energia e Materiais – CNPEM Rua Giuseppe M. Scolfaro, 10.000 – Guará Telefone: (19) 3512-1010
Seminar: RNAi applications in Drug Discovery
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilSpeaker: Dr. Lucio Freitas Junior (LNBio) 7th April 2014 at 8:30am Room 69 - LNBio Campus – Centro Nacional de Pesquisa em Energia e Materiais – CNPEM Rua Giuseppe M. Scolfaro, 10.000 – Guará Telefone: (19) 3512-1010
Seminar: How divergent cyclophilins regulate their isomerase activity
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilAbstract: The Citrus sinensis cyclophilin CsCyp is a target of the Xanthomonas citri TAL effector PthA, required to elicit tumors on citrus. CsCyp binds the C-terminal domain of the citrus RNA Polymerase II, affecting transcription of PthA-regulated genes. CsCyp belongs to the subfamily of divergent cyclophilins, which are characterized by an additional loop, the divergent […]
Seminar: I only have eye for ewe: genetic and chemical regulators of the Hedgehog pathway
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilAbstract: The Hedgehog (Hh) signaling pathway plays critical roles in embryonic patterning, tissue homeostasis, and tumorigenesis. In this seminar I will describe our laboratory’s use of genetic and chemical screens to identify new regulators of the Hh pathway. Using a genome-scale, flow cytometry-based survey of human cDNAs, we have discovered a novel signaling protein that […]
Seminar: I only have eye for ewe: genetic and chemical regulators of the patway
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilDonec eget mauris eleifend, dictum mi auctor, aliquet est. Sed mauris orci, suscipit ut eros vitae, rutrum lobortis arcu
Course on Preclinical Development of Biopharmaceuticals
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Workshop on Recent Advances and Applications in Confocal and Widefield Microscopy
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilCommunication of LNBio - 23rd April 2014 Available only in Portuguese Inscrições abertas para o “Workshop on Recent Advances and Applications in Confocal and Widefield Microscopy” Estão abertas, até 31 de maio, as inscrições para o Workshop on Recent Advances and Applications in Confocal and Widefield Microscopy. O evento será realizado entre os dias 6 e […]
Drug discovery for Chagas disease: where we stand and the way forward
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilAbstract: In this talk we will discuss the current panorama on Chagas disease drug discovery and the bottlenecks that are believed to have prevented more substantial advances towards new drugs in the past years. A still superficial understanding of the disease pathogenesis and the lack of screening assays and animal models that can correctly reproduce […]
The NIMA-family kinases Nek9, Nek6 and Nek7: regulating the centrosome cycle downstream of Plk1
CNPEM Rua Giuseppe Máximo Scolfaro, 10.000 , Campinas, São Paulo, BrazilAbstract: When eukaryotic cells divide, the correct segregation of the duplicated chromosomes to daughter cells depends on the organization and function of the mitotic spindle. In order to build this molecular machine the microtubule cytoskeleton is reorganized during mitosis into a bipolar array of unstable polymers connected to sister chromatids in a way that will […]
