{"id":57814,"date":"2025-10-07T10:30:51","date_gmt":"2025-10-07T13:30:51","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/?page_id=57814"},"modified":"2025-11-06T15:03:33","modified_gmt":"2025-11-06T18:03:33","slug":"quimica-medicinal","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/descoberta-de-farmacos\/quimica-medicinal\/","title":{"rendered":"Medicinal Chemistry"},"content":{"rendered":"

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Medicinal Chemistry<\/span><\/h1>\n

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  3. Medicinal Chemistry<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]Develops molecules with properties suitable for pharmaceutical candidates with efficacy in animal models, an essential step in pharmaceutical development. Medicinal chemistry approaches are adopted for rational planning of new pharmaceutically active chemical substances. This work is guided by the analysis of bioassay results and the prediction of drug properties, and production of molecules is mediated by in-house organic synthesis methodologies.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][vc_row_inner][vc_column_inner width=”1\/3″]\n\t
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    Competing interests during the key\u202fN-glycosylation of 6-chloro-7-deaza-7-iodopurine for the synthesis of 7-deaza-2\u2032-methyladenosine using Vorbr\u00fcggen conditions<\/h3>\t\t\t
    Fabr\u00edcio Fredo Naciuk, Andrey Fabricio Ziem Nascimento, Rebeca Paiva Froes Rocha, Joane Kathelen Rustiguel, Lais Dur\u00e7o Coimbra, Rafael Elias Marques, Marjorie Bruder<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Natural allosteric modulators and their biological targets: molecular signatures and mechanisms<\/h3>\t\t\t
    Marjorie Bruder, Gina Polo, Daniela B. B. Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor<\/h3>\t\t\t
    Gustavo Fernando Mercaldi, Eduardo Henrique Salviano Bezerra, Fernanda Aparecida Heleno Batista, Celisa Caldana Costa Tonoli, Adriana Santos Soprano, Jacqueline Farinha Shimizu, Alice Nagai, Jaqueline Cristina da Silva, Helder Veras Ribeiro Filho, J\u00e9ssica do Nascimento Faria, Marcos Guilherme da Cunha, Ana Carolina Mattos Zeri, Andrey Fabricio Ziem Nascimento, Jos\u00e9 Luiz Proenca-Modena, Marcio Chaim Bajgelman, Silvana Aparecida Rocco, Paulo S\u00e9rgio Lopes-de-Oliveira, Artur Torres Cordeiro, Marjorie Bruder, Rafael Elias Marques, Mauricio Luis Sfor\u00e7a, Kleber Gomes Franchini, Celso Eduardo Benedetti, Ana Carolina Migliorini Figueira, Daniela Barretto Barbosa Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16″][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
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    Marjorie C. P. Bruder<\/h2>
    Lead Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Fabricio Fredo Naciuk<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Anwar Shamin<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Kelita Angelo de Paula<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

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