{"id":57810,"date":"2025-10-07T10:19:59","date_gmt":"2025-10-07T13:19:59","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/?page_id=57810"},"modified":"2025-11-06T15:05:10","modified_gmt":"2025-11-06T18:05:10","slug":"farmacologia-molecular","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/descoberta-de-farmacos\/farmacologia-molecular\/","title":{"rendered":"Molecular Pharmacology"},"content":{"rendered":"

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Molecular Pharmacology<\/span><\/h1>\n

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  1. \r\n \r\n \r\n \r\n \r\n Home <\/a>\r\n <\/span>\r\n \r\n <\/li>
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  3. Molecular Pharmacology<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]Bioassays are used to evaluate large collections of molecules and select starting molecules for drug discovery projects. Highlights include structural biology approaches and biochemical, biophysical and cellular assays in high-throughput screening, as well as testing various cell types, including immortalized cells and human models derived from stem cells in two-dimensional (neurons and neural progenitors) and three-dimensional (neural organoids) modalities. Along with molecular biology tools, this group uses biotechnological routes to prospect for molecules of pharmaceutical interest.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][vc_row_inner][vc_column_inner width=”1\/3″]\n\t
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    High-throughput protein crystallography to empower natural product-based drug discovery<\/h3>\t\t\t
    Raphael Meneghello, Joane K Rustiguel, Evandro Ares de Ara\u00fajo, Rafael de Fel\u00edcio, Arthur Zanetti N Fernandes, Everton L F Ferreira, Juliana R Gubiani, Agnes A S Takeda, Amanda Araujo, Caio C de Lima Silva, Ariane F Bertonha, Raquel P M Urano, Daniel M Trindade, Thiago M Cunha, Alisson C Cardoso, Roberto G S Berlinck, Andrey F Ziem Nascimento, Daniela B B Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Production of Epoxyketone Peptide-Based Proteasome Inhibitors by\u202fStreptomyces\u202fsp. BRA-346: Regulation and Biosynthesis<\/h3>\t\t\t
    Bruna Domingues Vieira, Henrique Niero, Rafael de Fel\u00edcio, Luiz Fernando Giolo Alves, Cristina Freitas Bazzano, Renata Sigrist, Luciana Costa Furtado, Gabriela Felix Persinoti, Leticia Veras Costa-Lotufo, Daniela Barretto Barbosa Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Formal Total Synthesis of Actinoranone: Synthesis Approaches and Cytotoxic Studies<\/h3>\t\t\t
    Novaes et al., 2018<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16″][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
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    Daniela B. B. Trivella<\/h2>
    Lead Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Danieli Gon\u00e7alves<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Joane Kathelen Rustiguel Bonalumi<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Bruna Domingues Vieira<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Mariana Piccoli Goncalves<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Thais Hancio Pereira<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Beatriz Pelegrini Bosque<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Bruna Carla Casali<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Henrique Niero<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Isabelly Gon\u00e7alves Messias<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″][\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in drug discovery” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes” css=””][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]