{"id":57808,"date":"2025-10-07T10:10:44","date_gmt":"2025-10-07T13:10:44","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/?page_id=57808"},"modified":"2025-10-21T15:14:33","modified_gmt":"2025-10-21T18:14:33","slug":"produtos-naturais","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/descoberta-de-farmacos\/produtos-naturais\/","title":{"rendered":"Natural Products"},"content":{"rendered":"

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Natural Products<\/span><\/h1>\n

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  3. Natural Products<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]The Natural Products Group promotes the advancement of knowledge related to the chemistry of natural products through the development and application of innovative pipelines with a focus on discovering new drugs and preserving Brazil\u2019s biodiversity.<\/p>\n

    Through partnerships with companies and academia, the group’s main activities focus on: a) building libraries of natural products, using the organization of collections of chemical samples (extracts, fractions and purified compounds) obtained from plants, microorganisms, invertebrates (both marine and terrestrial), and other biological origins; b) chemical mapping of biodiversity via metabolomics using mass spectrometry, with a focus on the dereplication process; c) isolation of bioactive compounds to prove their chemical structures (when necessary); d) development of new methodologies for optimizing and automating results and processes.<\/p>\n

    The Natural Products Group works to integrate all these skills dynamically in order to highlight the vital importance of molecules from Brazil\u2019s biodiversity and of in-depth study of our living organisms, strengthening the concepts of preservation, innovation and sustainable use of natural resources.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][vc_row_inner][vc_column_inner width=”1\/3″]\n\t

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    NP3 MS Workflow: An Open-Source Software System to Empower Natural Product-Based Drug Discovery Using Untargeted Metabolomics<\/h3>\t\t\t
    Cristina F. BazzanoRafael de FelicioLuiz Fernando Giolo AlvesJonas Henrique CostaRaquel OrtegaBruna Domingues VieiraRaquel Peres Morais-UranoLuciana Costa FurtadoEverton L. F. FerreiraJuliana R. GubianiRoberto G. S. BerlinckLeticia V. Costa-LotufoGuilherme P. Telles*Daniela B. B. Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    A metabologenomics approach reveals the unexplored biosynthetic potential of bacteria isolated from an Amazon Conservation Unit<\/h3>\t\t\t
    Ana Carolina Favacho Miranda de Oliveira, Bruna Domingues Vieira, Rafael de Fel\u00edcio, Lucas da Silva e Silva, Adonney Allan de Oliveira Veras, Diego Assis das Gra\u00e7as, Artur Silva, Rafael Azevedo Bara\u00fana, Daniela Barretto Barbosa Trivella, Maria Paula Cruz Schneider<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions<\/h3>\t\t\t
    Rafael de Fel\u00edcio, Patricia Ballone, Cristina Freitas Bazzano, Cristina Freitas Bazzano, Luiz F. G. Alves, Renata Sigrist, Gina Polo Infante, Henrique Niero, Fernanda Rodrigues-Costa, Arthur Zanetti Nunes Fernandes, Luciane A. C. Tonon, Luciana S. Paradela, Renna Karoline Eloi Costa, Sandra Martha Gomes Dias, Andr\u00e9a Dessen, Guilherme P. Telles, Marcus Adonai Castro da Silva, Andre Oliveira de Souza Lima, Daniela Barretto Barbosa Trivella<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16″][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
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    Rafael de Fel\u00edcio<\/h2>
    Lead Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Ariane Fernandes Bertonha Delezuk<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    D\u00e9bora Munhoz Rodrigues<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Raquel Peres de Morais Urano<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” disable_element=”yes” css=”.vc_custom_1710441986322{background: #ffffff url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2023\/10\/padrao-bg-estreito-lnbio-pesquisa-e-desenvolvimento-tecnologias-para-saude-6.png?id=7665) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”virologia” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]<\/p>\n

    O Brasil e o mundo viram o impacto de viroses emergentes pand\u00eamicas n\u00e3o s\u00f3 sobre os sistemas p\u00fablicos e a sociedade. Al\u00e9m de contribuir de maneira importante para os estudos de SARS-CoV-2, o grupo de Virologia trabalha com foco especial em arboviroses, de olho em v\u00edrus ainda pouco estudados e transmitidos por vetores presentes em nosso ecossistema. Leia mais<\/strong><\/a><\/span><\/p>\n

    [\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”bact\u00e9rias” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]Exploramos o desenvolvimento de novos antibi\u00f3ticos, uma resposta inovadora e vital para enfrentar o desafio global das bact\u00e9rias multirresistentes, que representa uma preocupa\u00e7\u00e3o cr\u00edtica para a sa\u00fade p\u00fablica, tanto no Brasil quanto globalmente. Leia mais<\/strong><\/a><\/span>[\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in drug discovery” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes” css=””][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]