{"id":57804,"date":"2025-10-07T09:50:37","date_gmt":"2025-10-07T12:50:37","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/?page_id=57804"},"modified":"2025-10-21T15:09:58","modified_gmt":"2025-10-21T18:09:58","slug":"descoberta-e-validacao-de-alvos","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/descoberta-de-farmacos\/descoberta-e-validacao-de-alvos\/","title":{"rendered":"Target Discovery and Validation"},"content":{"rendered":"

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Target Discovery and Validation<\/span><\/h1>\n

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  3. Target Discovery and Validation<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]The Target Discovery and Validation research group focuses on identifying and validating therapeutic targets in order to develop new treatments for human diseases. The process begins with research to understand the molecular mechanisms of diseases such as neurodegenerative, cardiovascular, and metabolic disorders as well as cancer, selecting and validating relevant molecular targets to develop new therapies. This involves uses genetic and pharmacological target validation approaches, as well as the initial development of in vitro<\/em> and in vivo<\/em> models to interrogate them.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][vc_row_inner][vc_column_inner width=”1\/3″]\n\t
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    Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression<\/h3>\t\t\t
    Nature Metabolism, v. 2, p. 167-178, 2020<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure<\/h3>\t\t\t
    EBIOMEDICINE, v. 51, p. 102571, 2020<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes<\/h3>\t\t\t
    STRUCTURE, v. 24, p. 1301-1310, 2016<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16″][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
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    Alisson Campos Cardoso<\/h2>
    Lead Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Ana Helena Macedo Pereira<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Andrea Coelho de Barros<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Patr\u00edcia Nolasco Santos<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Taysa Bervian Bassani<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″][\/vc_column][vc_column width=”1\/4″][\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” disable_element=”yes” css=”.vc_custom_1710441986322{background: #ffffff url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2023\/10\/padrao-bg-estreito-lnbio-pesquisa-e-desenvolvimento-tecnologias-para-saude-6.png?id=7665) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”virologia” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]<\/p>\n

    O Brasil e o mundo viram o impacto de viroses emergentes pand\u00eamicas n\u00e3o s\u00f3 sobre os sistemas p\u00fablicos e a sociedade. Al\u00e9m de contribuir de maneira importante para os estudos de SARS-CoV-2, o grupo de Virologia trabalha com foco especial em arboviroses, de olho em v\u00edrus ainda pouco estudados e transmitidos por vetores presentes em nosso ecossistema. Leia mais<\/strong><\/a><\/span><\/p>\n

    [\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”bact\u00e9rias” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]Exploramos o desenvolvimento de novos antibi\u00f3ticos, uma resposta inovadora e vital para enfrentar o desafio global das bact\u00e9rias multirresistentes, que representa uma preocupa\u00e7\u00e3o cr\u00edtica para a sa\u00fade p\u00fablica, tanto no Brasil quanto globalmente. Leia mais<\/strong><\/a><\/span>[\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in drug discovery” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes” css=””][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]