{"id":57682,"date":"2025-09-15T09:01:25","date_gmt":"2025-09-15T12:01:25","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/?page_id=57682"},"modified":"2025-11-06T14:59:07","modified_gmt":"2025-11-06T17:59:07","slug":"estrutura-nuclear","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/biologia-integrativa\/estrutura-nuclear\/","title":{"rendered":"Nuclear Structure"},"content":{"rendered":"

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Nuclear Structure<\/span><\/h1>\n

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  3. Nuclear Structure<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]The Nuclear Structure Group at LNBio\/CNPEM emerged with a mission to reveal how the physical organization of the genome influences its function and, in turn, cell health. Using cutting-edge technologies in microscopy, structural biology and modeling, the group investigates how DNA folds, organizes and communicates within the nucleus.<\/p>\n

    The focus is on revealing how alterations in this architecture contribute to the onset and progression of diseases like cancer, neurodevelopmental disorders and neurodegenerative diseases. By investigating the structure of chromatin, nuclear compartments and architectural proteins, the group works to construct a new understanding of the genome: as not just a sequence of letters, but a dynamic structure that regulates cell destiny.<\/p>\n

    This knowledge will pave the way for innovative therapies and more precise approaches in combating diseases linked to nuclear disorganization.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row disable_element=”yes”][vc_column][vc_custom_heading text=”Principais resultados & publica\u00e7\u00f5es cient\u00edficas” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes”][vc_row_inner][vc_column_inner width=”1\/3″]\n\t

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    Open Science: Foldit\u2019s first outdoor experience in Brazil<\/h3>\t\t\t
    Using the software, kids and families learned about protein folding and how proteins can be designed for specific functions, including therapeutic applications, all in a relaxed, hands-on environment on a sunny day<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Simp\u00f3sio marca filia\u00e7\u00e3o do CNPEM \u00e0 RosettaCommons<\/h3>\t\t\t
    A RosettaCommons re\u00fane institui\u00e7\u00f5es de diversos pa\u00edses com o objetivo de acelerar o progresso da biologia estrutural por meio do compartilhamento cont\u00ednuo de algoritmos, dados e avan\u00e7os computacionais<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Sandra Martha Gomes Dias<\/h2>
    Lead Researcher (Interim)<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Andr\u00e9 Saraiva Le\u00e3o Marcelo Antunes<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Natalia Karla Bellini<\/h2>
    Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in integrative biology” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes” css=””][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]