{"id":52285,"date":"2024-03-15T09:33:31","date_gmt":"2024-03-15T12:33:31","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/divisoes-cientificas\/nucleos-avancados-saude\/biologicos\/"},"modified":"2024-08-26T09:58:49","modified_gmt":"2024-08-26T12:58:49","slug":"biologicos","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/nucleos-avancados-saude\/biologicos\/","title":{"rendered":"Biologicals"},"content":{"rendered":"

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Biologicals<\/span><\/h1>\n

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  3. Biologicals<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]Medications derived from biotechnological processes have revolutionized therapeutic strategies for various diseases. Recombinant proteins like the monoclonal antibodies used to treat cancer, for example, are produced in cell lines. These, in turn, must be established in laboratory structures that are equipped to construct vectors for expression, cell transfection, selection of producer clone candidates, as well as assays to characterize the lineages and the proteins they produce.<\/p>\n

    At LNBio, the process of establishing cell lines is conducted in order to create a cell bank for research, which is essential for producing therapeutic proteins in pre-clinical trials that are conducted in in vitro and in vivo models to evaluate safety, dose, and efficacy.<\/p>\n

    The objective is to establish new scientific and technological competencies that make it possible to generate active pharmaceutical ingredients that are of strategic importance in the production chain for biologicals. This includes lineages that produce recombinant proteins, contributing to Brazilian development of innovative medications and biosimilars that can benefit the public health system.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row disable_element=”yes”][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes”][vc_row_inner][vc_column_inner width=”1\/3″]\n\t

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    Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer<\/h3>\t\t\t
    Busso-Lopes AF, Neves LX, C\u00e2mara GA, Granato DC, Pretti MAM, Heberle H, Patroni FMS, S\u00e1 J, Yokoo S, Rivera C, Domingues RR, Normando AGC, De Rossi T, Mello BP, Galdino NAL, Pauletti BA, Lacerda PA, Rodrigues AAN, Casarim ALM, de Lima-Souza RA, Damas II, Mariano FV, Gollob KJ, Medina TS, Cervigne NK, Prado-Ribeiro AC, Brand\u00e3o TB, Villa LL, Uno M, Boroni M, Kowalski LP, Gonz\u00e1lez-Arriagada WA, Paes Leme AF<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer<\/h3>\t\t\t
    \uf0d8 Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, Pauletti BA, Yokoo S, Heberle H, Busso-Lopes AF, Cervigne NK, Sawazaki-Calone I, Meirelles GV, Marchi FA, Telles GP, Minghim R, Ribeiro ACP, Brand\u00e3o TB, de Castro G Jr, Gonz\u00e1lez-Arriagada WA, Gomes A, Penteado F, Santos-Silva AR, Lopes MA, Rodrigues PC, Sundquist E, Salo T, da Silva SD, Alaoui-Jamali MA, Graner E, Fox JW, Coletta RD, Paes Leme AF<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Identification of novel interaction between ADAM17 (a disintegrin and metalloprotease 17) and thioredoxin-1<\/h3>\t\t\t
    Arag\u00e3o AZ, Nogueira ML, Granato DC, Simabuco FM, Honorato RV, Hoffman Z, Yokoo S, Laurindo FR, Squina FM, Zeri AC, Oliveira PS, Sherman NE, Paes Leme AF<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″][vc_custom_heading text=”meet
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    Marcio Chaim Bajgelman<\/h2>
    Lead researcher (interim)<\/div>

    biological group<\/strong>
    \nSee Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″][\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in advanced health technologies” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes”][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]