{"id":52275,"date":"2024-03-14T14:18:11","date_gmt":"2024-03-14T17:18:11","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/divisoes-cientificas\/biologia-integrativa\/biologia-do-cancer\/"},"modified":"2025-10-21T11:18:44","modified_gmt":"2025-10-21T14:18:44","slug":"sociologia-molecular-e-celular","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/biologia-integrativa\/sociologia-molecular-e-celular\/","title":{"rendered":"Molecular and Cellular Sociology"},"content":{"rendered":"

[vc_row full_width=”stretch_row” full_height=”yes” content_placement=”middle” parallax=”content-moving” parallax_image=”57673″ el_class=”fundo-escuro”][vc_column width=”1\/2″][vc_column_text css=””]<\/p>\n

Molecular and Cellular Sociology<\/span><\/h1>\n

[\/vc_column_text][vc_column_text css=”.vc_custom_1696512384777{margin-left: -15px !important;border-left-width: -15px !important;padding-left: -15px !important;}”]\t\t\t\r\n\t\t\t

\r\n\r\n\t\t\t\t\r\n\t\t\t\t
\r\n\r\n\t\t\t\t\t\r\n\t\t\t\t\t
    \r\n\t\t\t\t\t\t
  1. \r\n \r\n \r\n \r\n \r\n Home <\/a>\r\n <\/span>\r\n \r\n <\/li>
  2. \/<\/span><\/li>
  3. Molecular and Cellular Sociology<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]LNBio’s Molecular and Cellular Sociology Group is dedicated to the study of functional interactions between molecules and cells within the native tissue environment, with a focus on understanding the mechanisms that sustain the progression of diseases such as cancer. This group investigates how proteins, enzymes and molecular complexes are organized spatially within cells, and how these structures shape cellular and intercellular behavior, especially in pathological contexts.<\/p>\n

    The use of advanced approaches like three-dimensional cultivation of tumor organoids makes it possible to faithfully reproduce human tumor microenvironments. These models are essential for evaluating conventional chemotherapy and developing personalized treatment strategies, with special attention to cases of refractory tumors, where the available therapies have low efficacy.<\/p>\n

    This research group also explores microfluidic-based platforms to simulate metastasis and cellular interactions in controlled environments. It combines these technologies with molecular biology and biochemistry tools to investigate metabolic adaptations, immunosuppression and the quinary structure of enzymes directly in cells.<\/p>\n

    The goal of the Molecular and Cellular Sociology Group is to help advance more effective therapies by understanding how tumor cells and immune cells interact and influence the tumor microenvironment, at the molecular scale. Based on this knowledge, the group looks for intervention strategies that can be translated into concrete clinical benefits for patients.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][vc_row_inner][vc_column_inner width=”1\/3″]\n\t

    \n\t\n\t\t\t\t
    \n\t\t\t

    Returning home: fostering growth of Brazilian research<\/h3>\t\t\t
    Dias SMG<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
    \n\t\n\t\t\t\t
    \n\t\t\t

    GLS2 is protumorigenic in breast cancers<\/h3>\t\t\t
    Marilia M. Dias, Douglas Adamoski, Larissa M. dos Reis, Carolline F. R. Ascen\u00e7\u00e3o, Krishina R. S. de Oliveira, Ana Carolina Paschoalini Mafra, Alliny Cristiny da Silva Bastos, Melissa Quintero, Carolina de G. Cassago, Igor M. Ferreira, Carlos H. V. Fidelis, Silvana A. Rocco, Marcio Chaim Bajgelman, Zachary Stine, Ioana Berindan-Neagoe, George A. Calin, Andre Luis Berteli Ambrosio & Sandra Martha Gomes Dias<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
    \n\t\n\t\t\t\t
    \n\t\t\t

    Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection<\/h3>\t\t\t
    Douglas Adamoski, Marilia Meira Dias, Jose Edwin Neciosup Ques\u00f1ay, Zhengyi Yang, Ievgeniia Zagoriy, Anna M. Steyer, Camila Tanimoto Rodrigues, Alliny Cristiny da Silva Bastos, Bianca Novaes da Silva, Renna Karoline Eloi Costa, Fl\u00e1via Mayumi Odahara de Abreu, Zeyaul Islam, Alexandre Cassago, Marin Gerard van Heel, S\u00edlvio Roberto Consonni, Simone Mattei, Julia Mahamid, Rodrigo Villares Portugal, Andre Luis Berteli Ambrosio & Sandra Martha Gomes Dias<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16px”][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Sandra Martha Gomes Dias<\/h2>
    Lead Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Alex Castro<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Guilherme Henrique Tamarindo<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Queila Cristina Dias<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Raquel Arminda Martinez Machado<\/h2>
    Adjunct Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Renata Spagolla Napole\u00e3o Tavares<\/h2>
    Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Alessandra Girasole<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in integrative biology” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes” css=””][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]