{"id":52274,"date":"2024-03-15T08:03:49","date_gmt":"2024-03-15T11:03:49","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/divisoes-cientificas\/biologia-integrativa\/biologia-computacional\/"},"modified":"2025-11-06T14:58:10","modified_gmt":"2025-11-06T17:58:10","slug":"biologia-computacional","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/biologia-integrativa\/biologia-computacional\/","title":{"rendered":"Computational biology"},"content":{"rendered":"

[vc_row full_width=”stretch_row” full_height=”yes” content_placement=”middle” parallax=”content-moving” parallax_image=”51459″ el_class=”fundo-escuro”][vc_column][vc_column_text]<\/p>\n

Computational biology<\/span><\/h1>\n

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  3. Computational biology<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]The areas of biotechnology have benefited significantly in recent decades from advances in science and technology which have led to the production of large quantities of data on biological systems. Today, a biological process can be approached considering gene architecture, protein structure and diversity, as well as the diversity of these events within the population (population genetics).<\/p>\n

    This approach makes it possible to characterize the functional potential of biological systems through spatial, temporal, and environmental analyses, revealed by genomic, proteomic, and transcriptomic data. The complexity of these data demand parallel development of data analysis, modeling strategies, and computational structure compatible with the magnitude of the problems.<\/p>\n

    LNBio stands out in the development of precise theoretical computational models, using experimental data from biological macromolecules and high-performance processing. These models provide researchers with a better understanding of the biological function of biomacromolecular systems, allowing hypotheses to be developed and analyzed in silico. This accelerates the production of accurate results, conserving resources and reducing the costs involved in experimentation.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes”][vc_row_inner][vc_column_inner width=”1\/3″]\n\t

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    KVFinder-web: a web-based application for detecting and characterizing biomolecular cavities<\/h3>\t\t\t
    Guerra JVS, Ribeiro-Filho HV, Pereira JGC, Lopes-de-Oliveira PS<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding<\/h3>\t\t\t
    Ribeiro-Filho HV, Jara GE, Batista FAH, Schleder GR, Costa Tonoli CC, Soprano AS, Guimar\u00e3es SL, Borges AC, Cassago A, Bajgelman MC, Marques RE, Trivella DBB, Franchini KG, Figueira ACM, Benedetti CE, Lopes-de-Oliveira PS<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Revisiting protein kinase-substrate interactions: Toward therapeutic development<\/h3>\t\t\t
    de Oliveira PS, Ferraz FA, Pena DA, Pramio DT, Morais FA, Schechtman D<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
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    Sandra Martha Gomes Dias<\/h2>
    Lead Researcher (Interim)<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Gabriel Ernesto Jara<\/h2>
    Specialist<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Gabriel Felipe Totene<\/h2>
    Analyst<\/div>

    See Lattes CV<\/a><\/p><\/div>

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    Leandro Oliveira Bortot<\/h2>
    Researcher<\/div>

    See Lattes CV<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in integrative biology” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes”][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]