{"id":52268,"date":"2024-03-14T13:10:49","date_gmt":"2024-03-14T16:10:49","guid":{"rendered":"https:\/\/lnbio.cnpem.br\/divisoes-cientificas\/imunidade-e-patogenos\/chagas\/"},"modified":"2025-10-21T10:10:25","modified_gmt":"2025-10-21T13:10:25","slug":"doencas-tropicais-negligenciadas","status":"publish","type":"page","link":"https:\/\/lnbio.cnpem.br\/en\/divisoes-cientificas\/imunidade-e-patogenos\/doencas-tropicais-negligenciadas\/","title":{"rendered":"Neglected Tropical Diseases"},"content":{"rendered":"

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Neglected Tropical Diseases<\/span><\/h1>\n

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  3. Neglected Tropical Diseases<\/span><\/li>\t\t\t\t\t<\/ol>\r\n\t\t\t\t\t
    <\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”5″ css=”.vc_custom_1710932812600{padding-top: 4rem !important;padding-bottom: 4rem !important;background-image: url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2024\/03\/grafismo-organico-lnbio-cinza.png?id=35463) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_column_text css=””]The research group that focuses on neglected diseases works to advance by means of scientific knowledge to combat infectious diseases that affect more vulnerable populations. It studies proteins in parasites in order to discover small molecules that affect their function in order to consequently control the progress of these diseases. The group focuses on proteins in Trypanosoma cruzi<\/em> to discover drugs with potential use against Chagas disease, combining techniques like X-ray crystallography, high-throughput screening, metabolomics, transcriptomics, medicinal chemistry and animal testing in order to develop potential medications with proven efficacy in animal models.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Main findings and scientific publications” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes”][vc_row_inner][vc_column_inner width=”1\/3″]\n\t
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    Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability<\/h3>\t\t\t
    Faria JDN, Eufr\u00e1sio AG, Fagundes M, Lobo-Rojas A, Marchese L, de Lima Silva CC, Bezerra EHS, Mercaldi GF, Alborghetti MR, Sforca ML, Cordeiro AT<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium<\/h3>\t\t\t
    Mercaldi GF, Andrade MO, Zanella JL, Cordeiro AT, Benedetti CE<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][vc_column_inner width=”1\/3″]\n\t
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    Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box<\/h3>\t\t\t
    Mercaldi GF, Eufr\u00e1sio AG, Ranzani AT, do Nascimento Faria J, Mota SGR, Fagundes M, Bruder M, Cordeiro AT<\/div>\t\t<\/div>\n\t\t<\/span>\n\t<\/a>\n\n\t\t<\/div>\n\n\t[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”32″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696515988446{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”16px”][vc_custom_heading text=”meet our team” font_container=”tag:h3|text_align:left” use_theme_fonts=”yes” css=””][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1696516377387{background-color: #eff2f5 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/4″]
    \"\"<\/span><\/div>

    Artur Torres Cordeiro<\/h2>
    Lead Researcher<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Gustavo Fernando Mercaldi<\/h2>
    Researcher<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Celso Eduardo Benedetti<\/h2>
    Senior Researcher<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Cristiane Tambascia Pereira<\/h2>
    Specialist<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Let\u00edcia Marchese<\/h2>
    Analyst<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Michelle Fagundes<\/h2>
    Analyst<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

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    \"\"<\/span><\/div>

    Jaqueline Cristina da Silva<\/h2>
    Analyst<\/div>

    Ver curr\u00edculo Lattes<\/a><\/p><\/div>

    <\/div><\/div><\/div><\/div>[\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1696434766725{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_empty_space height=”40″][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” disable_element=”yes” css=”.vc_custom_1710441986322{background: #ffffff url(https:\/\/lnbio.cnpem.br\/wp-content\/uploads\/2023\/10\/padrao-bg-estreito-lnbio-pesquisa-e-desenvolvimento-tecnologias-para-saude-6.png?id=7665) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”virology” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]<\/p>\n

    O Brasil e o mundo viram o impacto de viroses emergentes pand\u00eamicas n\u00e3o s\u00f3 sobre os sistemas p\u00fablicos e a sociedade. Al\u00e9m de contribuir de maneira importante para os estudos de SARS-CoV-2, o grupo de Virologia trabalha com foco especial em arboviroses, de olho em v\u00edrus ainda pouco estudados e transmitidos por vetores presentes em nosso ecossistema. Leia mais<\/strong><\/a><\/span><\/p>\n

    [\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][vc_column width=”1\/2″][vc_empty_space height=”10px”][vc_custom_heading text=”bacterie” font_container=”tag:h4|text_align:left|color:%23ffffff”][vc_separator color=”custom” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”none” accent_color=”#ffffff”][vc_empty_space height=”10px”][vc_column_text]Exploramos o desenvolvimento de novos antibi\u00f3ticos, uma resposta inovadora e vital para enfrentar o desafio global das bact\u00e9rias multirresistentes, que representa uma preocupa\u00e7\u00e3o cr\u00edtica para a sa\u00fade p\u00fablica, tanto no Brasil quanto globalmente. Leia mais<\/strong><\/a><\/span>[\/vc_column_text][vc_empty_space height=”10px”][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1705339428945{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=”All groups in immunity and pathogens” font_container=”tag:h3|text_align:left|color:%23111111″ use_theme_fonts=”yes”][vc_separator color=”green” align=”align_left” border_width=”5″ el_width=”10″ css_animation=”slideInLeft”][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1710441827678{background-color: #ffffff !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column][vc_row_inner][vc_column_inner]