The Laboratory of Bioinformatics (LBI) was created to meet the needs of storing and analyzing the data sets of biological data whose complexity requires the use of statistical, mathematical and computational methods. The LBI, is an unusual model in Brazil, presenting scientific cores that meet both the demand for research in bioinformatics applied to structural biology as well as in bioinformatics applied to genomics, transcriptomics, metabolomics and proteomics.
The main focus of the bioinformatics structural core is the application of computational methods for the study of intermolecular interactions in biological and pathological models. Among the protocols in place, we highlight the computational platform that allows the analysis of the binding potential of small molecules to proteins, coupled with new methods of computational analysis devoted to obtaining the structural features of cavities in proteins, with a strong involvement in studies for the development of new therapeutic agents . Also, in the field of functional characterization of proteins, LBI works with a number of protocols in silico structural determination and molecular dynamics simulation, which allows researchers to accurately predict the experimental molecular features to be explored in bench experiments.
The bioinformatics core is focused on experimental design and data analysis related to genomes, transcriptomes, proteomes conducts applied research on human health and agricultural solutions. This core develops protocols for computational analysis of metagenomics, the analysis of differential gene expression in microarray data and next-generation sequencing, and analysis of protein-protein interaction generated in proteomics experiments and two-hybrid.